Friday, 20 February 2015

Vancomycin

                             VANCOMYCIN

Vancomycin comes under a group called as GLYCOPEPTIDES. Other drugs in this group are Teicoplanin , Oritavaricin , Telavancin , Dalbavancin . All glycopeptides inhibit cell wall synthesis in bacteria .
MECHANISM OF ACTION : 
  1. They are bacteriocidal antibiotics .
  2. They inhibit cell wall synthesis by inhibiting TRANSGLYCOLASE enzyme required for polypeptide chain elongation.
PHARMACOLINETICS:
  1. Vancomycin taken as I.V 
  2. It is not absorbed when given orally . It is given orally for Pseudomembranous colitis by Clostridium difficile  
  3. They are excreted in Urine
USE:
  1. MRSA
  2. Clostridium jeikium 
  3. Penicillin allergic patients as an alternative drug 
  4. Pseudomembranous colitis by Clostridium difficile 
ADVERSE EFFECTS:
  1. Rapid I.V infusion of vancomycin can lead to RED MAN SYNDROME ( diffuse flushing ) . Because vancomycin releases histamine .
  2. Ototoxicity
  3. Nephrotoxicity
  4. Chills

                                      

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